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Optimizing Protein Design with Reinforcement Learning-Enhanced pLMs: Introducing DPO_pLM for Efficient and Targeted Sequence Generation
Autoregressive protein language models (pLMs) have become transformative tools for designing functional proteins with remarkable diversity, demonstrating success in creating enzyme families like lysozymes and carbonic anhydrases. These models generate protein sequences by sampling from learned probability distributions, uncovering intrinsic patterns within training datasets. Despite their ability to explore high-quality subspaces of the sequence landscape,…
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OpenAI confirms new frontier models o3 and o3-mini
OpenAI has just confirmed that is releasing a new reasoning model named o3 and o3 mini, a successor to the o1 and o1 mini models.Read More
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Tomás Carbonell (Wiz): “2025 va a ser el año en el que el SOC conecte con la nube”
La compañía de seguridad Wiz, que este 2024 era noticia por el intento de compra por parte de Alphabet (matriz de Google), operación que finalmente la exitosa startup rechazó, ha sido uno de los patrocinadores de la última edición de los CIO 100 Awards Spain; unos galardones que, en palabras de Tomás Carbonell, vicepresidente regional…
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Hugging Face Releases FineMath: The Ultimate Open Math Pre-Training Dataset with 50B+ Tokens
For education research, access to high-quality educational resources is critical for learners and educators. Often perceived as one of the most challenging subjects, mathematics requires clear explanations and well-structured resources to make learning more effective. However, creating and curating datasets focusing on mathematical education remains a formidable challenge. Many datasets for training machine learning models…
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The last day of ’12 days of OpenAI’ is expected to bring biggest drop yet
If you thought the o1 reasoning models were impressive, you may be in for a treat.
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Why Can’t You Switch Seats in an Empty Airplane?
Yes, the weight distribution on an aircraft really does affect how well it flies. Our physics guy explains.
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Puzzle Corner September/October 2024 bonus solutions
Here are solutions for the three bonus problems that appeared in the September/October 2024 Puzzle Corner column we guest edited. Solutions for S/O2, S/O4, and S/O6 are below; those for S/O1, S/O3, and S/O5 can be found here. S/O2. Frank notes that a repunit Rk is a decimal integer consisting of the digit 1 repeated…
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Puzzle Corner
Ready for a fresh set of puzzles? Click here for the January/February Puzzle Corner, brought to you with a special Mystery Hunt twist by guest editor Dan Katz ’03. This column includes solutions to three September/October 24 problems. Find solutions to the other three problems here.
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‘Batman: Arkham Shadow’ Proves VR Gaming Isn’t Just a Gimmick
The latest Batman outing for Meta Quest shows that, when done well, VR gaming can hold its own with any platform.
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Indiana Jones and the Great Circle Review: Fortune and Glory
A combination of puzzle-solving, bare-knuckle boxing, and brilliant performances recall the best of Indy’s adventures.